
Thibault Jacques Dit Lapierre
Thibault Jacques Dit Lapierre received his Master’s degree in Chemistry of Biomolecules – Research & Innovation from the École Nationale Supérieure de Chimie de Montpellier (ENSCM, Montpellier, France) in 2020. His Master’s research was carried out at the Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute (Leibniz-HKI) in Jena, Germany, where he focused on optimising the synthesis of antitubercular nitrobenzothiazinone derivatives and synthesising new A-ring derivatives of the same class, under the supervision of Dr. Florian Kloss. Following his M. Sc., he pursued his Ph. D. in Medicinal Chemistry at the Federal University of Uberlândia (UFU, Uberlândia, Brazil) under the supervision of Prof. Dr. Celso de Oliveira Rezende Júnior, which he received in 2025. His doctoral research involved the hit-to-lead optimisation of a series of pyrazinylpiperazine derivatives and a series of 2-ethyl-4-phenylthiazoles against visceral leishmaniasis and Chagas disease, focusing on the design and synthesis of new analogues within each class. In 2026, he joined the Medicinal Chemistry unit of Rega Institute as a postdoctoral researcher, under the supervision of Prof. Dr. Peter Verwilst.
In line with his previous research experience with anti-infectives, his current research aims at optimising a class of FabV inhibitors to develop new antibacterial compounds against Pseudomonas aeruginosa.
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Research Interests
15. Piperazine and Morpholine Protoporphyrin IX Derivatives Intensify Biomolecules Oxidation and Phototoxicity in Triple-Negative Breast Cancer
Maynne Duarte Suriani Franco, Thibault Joseph William Jacques Dit Lapierre, Tarcisio Paiva Mendonça, Luiz Felipe Fernandes Peixoto, Renata Roland Teixeira, Joyce Ferreira Da Costa Guerra, Kelly Aparecida Geraldo Yoneyama Tudini, Daniele Lisboa Ribeiro, Foued Salmen Espindola, Allisson Benetti Justino, Celso de Oliveira Rezende Júnior, Tayana Mazin Tsubone, ChemMedChem 2026, 21, e70471. Read here
14. Identification of a Benzenesulfonylpiperazine Derivative With In Vivo Efficacy Against Visceral Leishmaniasis
Thibault Joseph William Jacques Dit Lapierre, Mariza Gabriela Faleiro de Moura Lodi Cruz, Guilherme Freitas de Lima Hercos, Rafael Consolin Chelucci, Simone Michelan-Duarte, Gisele Barbosa, Analu R. Costa, Miguel Angel Chávez-Fumagalli, Paula Derksen Macruz, Eduardo Jorge Pilau, Leonardo L. G. Ferreira, Adriano D. Andricopulo, Silvane Maria Fonseca Murta, Celso de Oliveira Rezende Júnior, Chemical Biology & Drug Design 2026, 108, e70367. Read here
13. Discovery of an efficacious 2-ethyl-4-phenylthiazole derivative against acute Chagas disease via multiparametric hit-to-lead optimization and in vivo efficacy
Thibault Joseph William Jacques Dit Lapierre, Mariza Gabriela Faleiro de Moura Lodi Cruz, Gisele Barbosa, Analu R. Costa, Miguel Angel Chávez-Fumagalli, Thamires Quadros Froes, Priscila Zonzini Ramos, Paula Derksen Macruz, Thalita Carolyne Souza Trindade, Eduardo Jorge Pilau, Patricia Sampaio Tavares Veras, Maria Cristina Nonato, Katlin B. Massirer, Leonardo L. G. Ferreira, Adriano D. Andricopulo, Lídia Moreira Lima, Silvane Maria Fonseca Murta, Celso de Oliveira Rezende Júnior, European Journal of Medicinal Chemistry 2026, 313, 118888. Read here
12. Hit-to-Lead Studies of Pyrazinylpiperazines against Visceral Leishmaniasis: Pharmacokinetic Profile and In Vivo Efficacy of Potent Compounds against Leishmania infantum
Thibault Joseph William Jacques Dit Lapierre, Mariza Gabriela Faleiro de Moura Lodi Cruz, Gisele Barbosa, Analu R. Costa, Miguel Angel Chávez-Fumagalli, Thamires Quadros Froes, Priscila Zonzini Ramos, Paula Derksen Macruz, Thalita Carolyne Souza Trindade, Eduardo Jorge Pilau, Patricia Sampaio Tavares Veras, Maria Cristina Nonato, Katlin B. Massirer, Leonardo L. G. Ferreira, Adriano D. Andricopulo, Lídia Moreira Lima, Silvane Maria Fonseca Murta, Celso de Oliveira Rezende Júnior, ACS Pharmacology & Translational Science 2025, 8, 2736–2755. Read here
11. Protoporphyrin IX conjugated to piperazine or morpholine: Photophysical properties and photodynamic activity
Maynne Duarte Suriani Franco, Thibault Joseph William Jacques Dit Lapierre, Ana Clara Cassiano Martinho, Naiara Cristina Bessas, Mayara Martins Caetano, Thiago Teixeira Tasso, Marcelo Emílio Beletti, Renata Galvão de Lima, Celso de Oliveira Rezende Júnior, Tayana Mazin Tsubone, Dyes and Pigments 2025, 236, 112649. Read here
10. Discovery of Arylpiperazines with Broad-Spectrum Antimicrobial Activity and Favorable Pharmacokinetic Profiles
Douglas Davison da Silva Oliveira, Nagela Bernadelli Sousa Silva, Thibault Joseph William Jacques Dit Lapierre, Sara Lemes de Souza, Nícolas Peterson Ferreira Brito, Ana Clara Cassiano Martinho, Renieidy Flávia Clemente Dias, Danilo Nascimento Farago, Simone Michelan-Duarte, Rafael Consolin Chelucci, Mariza Gabriela Faleiro de Moura Lodi Cruz, Daniela de Melo Resende, Adriano D. Andricopulo, Silvane Maria Fonseca Murta, Leonardo L. G. Ferreira, Carlos Henrique Gomes Martins, Celso de Oliveira Rezende Júnior, Chemistry & Biodiversity 2025, 22, e202402100. Read here
9. Modulation of the Meisenheimer complex metabolism of nitro-benzothiazinones by targeted C-6 substitution
François Keiff, Freddy A. Bernal, Melanie Joch, Thibault J. W. Jacques dit Lapierre, Yan Li, Phil Liebing, Hans-Martin Dahse, Ivan Vilotijevic, Florian Kloss, Communications Chemistry 2024, 7, 153. Read here
8. Synthesis, design, and optimization of a potent and selective series of pyridylpiperazines as promising antimalarial agents
Douglas Davison da Silva Oliveira, Franciarli Paz, Nícolas Peterson Ferreira Brito, Arne Krüger, Ana Clara Cassiano Martinho, Thibault Joseph William Jacques Dit Lapierre, Felipe de Oliveira Souza, Vinícius G. Maltarollo, Thales Kronenberger, Marina Sena Mendes, Maria Cristina Nonato, Eduardo Jorge Pilau, Carsten Wrenger, Gerhard Wunderlich, Celso de Oliveira Rezende Júnior, European Journal of Medicinal Chemistry 2024, 275, 116621. Read here
7. New drug discovery strategies for the treatment of benznidazole-resistance in Trypanosoma cruzi, the causative agent of Chagas disease
Silvane Maria Fonseca Murta, Pedro Augusto Lemos Santana, Thibault Joseph William Jacques Dit Lapierre, André Berndt Penteado, Marissa El Hajje, Thabata Corazza Navarro Vinha, Daniel Barbosa Liarte, Mariana Laureano de Souza, Gustavo Henrique Goulart Trossini, Celso de Oliveira Rezende Júnior, Renata Barbosa de Oliveira, Rafaela Salgado Ferreira, Expert Opinion on Drug Discovery 2024, 19, 741–753. Read here
6. Evaluation and discovery of novel benzothiazole derivatives as promising hits against Leishmania infantum
Thibault Joseph William Jacques Dit Lapierre, Danilo Nascimento Farago, Mariza Gabriela Faleiro de Moura Lodi Cruz, Daniela de Melo Resende, Adriane Cristina Rosa de Oliveira, Brenda Rosa Macedo dos Santos, Felipe de Oliveira Souza, Simone Michelan-Duarte, Rafael C. Chelucci, Adriano D. Andricopulo, Leonardo L. G. Ferreira, Eduardo Jorge Pilau, Silvane Maria Fonseca Murta, Celso de Oliveira Rezende Júnior, Chemical Biology & Drug Design 2024, 103, e14525. Read here
5. Advances in Breast Cancer Drug Discovery: A Review of Therapeutic Strategies and Studies Involving Photosensitizers, Caged Xanthones and Thiosemicarbazones Derivatives
Douglas D. S. Oliveira, Thibault J. W. Jacques Dit Lapierre, Fernanda C. Silva, Ieda V. Cunha, Rafael A. C. Souza, Patrícia A. Matos, Gustavo M. Almeida, Carolina G. Oliveira, Thaise G. Araújo, Tayana M. Tsubone, Celso O. Rezende Júnior, Journal of the Brazilian Chemical Society 2024, 35, 1–32. Read here
4. Design and synthesis of benzofuran- and naphthalene-fused thiazinones as antimycobacterial agents
Mariana Laureano de Souza, Thibault Joseph William Jacques Dit Lapierre, Gabriel Vitor de Lima Marques, Witor Ribeiro Ferraz, André Berndt Penteado, Gustavo Henrique Goulart Trossini, Silvane Maria Fonseca Murta, Renata Barbosa de Oliveira, Celso de Oliveira Rezende Júnior, Rafaela Salgado Ferreira, Expert Opinion on Therapeutic Targets 2023, 27, 911–925. Read here
3. Design and synthesis of benzofuran- and naphthalene-fused thiazinones as antimycobacterial agents
François Keiff, Thibault J. W. Jacques dit Lapierre, Freddy A. Bernal, Florian Kloss, Archiv der Pharmazie – Chemistry in Life Sciences 2023, 356, 2300356. Read here
2. Hit-to-lead optimization of a pyrazinylpiperazine series against Leishmania infantum and Leishmania braziliensis
Thibault Joseph William Jacques Dit Lapierre, Mariza Gabriela Faleiro de Moura Lodi Cruz, Nícolas Peterson Ferreira Brito, Daniela de Melo Resende, Felipe de Oliveira Souza, Eduardo Jorge Pilau, Meryck Felipe Brito da Silva, Bruno Junior Neves, Silvane Maria Fonseca Murta, Celso de Oliveira Rezende Júnior, European Journal of Medicinal Chemistry 2023, 256, 115445. Read here
1. Synthesis, Design, and Structure-Activity Relationship of a Benzenesulfonylpiperazine Series against Trypanosoma cruzi
Ana Clara Cassiano Martinho, Daniela de Melo Resende, Emanuelly Silva Landin, Thibault Joseph William Jacques Dit Lapierre, Talita Cristina Diniz Bernardes, Luan Carvalho Martins, Rafaela Salgado Ferreira, Silvane Maria Fonseca Murta, Celso de Oliveira Rezende Júnior, ChemMedChem 2022, 17, e202200211. Read here