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Eline Goffin

Eline Goffin graduated as a Master in Chemistry at KU Leuven in 2019, following her Bachelor’s degree in Chemistry obtained at Hasselt University in 2017. During the second year of her Master’s studies she joined the laboratory of Prof. Dr. Wim Dehaen for her Master’s thesis, entitled 'Synthesis and biological evaluation of polyazaheterocyclic and isoquinoline based compounds as CXCR4 antagonists'. After graduating in 2019, she joined the Verwilst Lab at the Rega Institute for Medicinal Research to pursue a PhD in Drug Design and Development.
Her PhD project focusses on the development of small-molecule drugs as a potential CNS specific therapy in Alzheimer’s disease as well as the design of novel antiviral drugs that target HIV reverse transcriptase enzyme. Within her PhD project, several aspects of Medicinal Chemistry research are addressed, with a main focus on the synthesis of organic small-molecule drugs.

CV

  • 2019 - current - PhD in Pharmaceutical Sciences - KU Leuven
  • 2017 - 2019 - Master in Chemistry - KU Leuven
  • 2014 - 2017 - Bachelor in Chemistry - Hasselt University

Research Interests

  • Medicinal Chemistry
  • Organic Synthesis
  • Drug Design
  • Neurodegenerative Diseases
  • Antiviral Research
Publications

1. Synthesis and Anti-HIV Activity of a Novel Series of Isoquinoline-based CXCR4 Antagonists
Mastaneh Safarnejad Shad, Sandra Claes, Eline Goffin, Tom Van Loy, Dominique Schols, Steven De Jonghe, Wim Dehaen, Molecules 2021, 26, 6297. Read here

PREPRINT. Discovery and SAR Exploration of Novel Nanomolar 3,4-dihydroquinazolin-2(1H)-one Non-Nucleoside Reverse Transcriptase Inhibitors
Eline Goffin, Laurynn Torfs, David Švestka, Kristien Erven, Kris Uyttersprot, Cindy Heens, Simon Wilms, Jef Rozenski, Eveline Lescrinier, Christophe Pannecouque, Peter Verwilst, ChemRxiv 2025. Read here

2. Discovery and SAR Exploration of Novel Nanomolar 3,4-dihydroquinazolin-2(1H)-one Non-Nucleoside Reverse Transcriptase Inhibitors
Eline Goffin, Laurynn Torfs, Fanos Tsingis, David Švestka, Kristien Erven, Kris Uyttersprot, Cindy Heens, Simon Wilms, Jef Rozenski, Eveline Lescrinier, Christophe Pannecouque, Peter Verwilst, European Journal of Medicinal Chemistry 2025, accepted. Read here